期刊论文

中文

中国中药杂志

1001-5302

2023

48

23

6475-6482

10.19540/j.cnki.cjcmm.20230914.701

82274412:国家自然科学基金 81774208:国家自然科学基金 2020B1111100001:广东省重点领域研发计划项目 2022CX47:湖南中医药大学校级研究生创新课题

本校为第一机构

基于NOD样受体热蛋白结构域相关蛋白3（NOD-like receptor thermal protein domain associated protein 3, NLRP3）/半胱氨酸蛋白酶-1（caspase-1）信号通路探讨参附注射液干预慢性心力衰竭的机制及作用靶点。采用皮下注射异丙肾上腺素法建立慢性心力衰竭大鼠模型，造模成功的大鼠用随机数字表法分为模型组、参附注射液组、MCC950（NLRP3抑制剂）组，另设空白组，给药15 d后超声心电图检测各组大鼠心功能指标[左室射血分数（left ventricular ejection fraction, LVEF）、左室缩短分数（left ventricular dysfunction, LVFS）];酶联免疫吸附（enzyme-linked immunosorbent assay, ELISA）法检测...

This study investigated the mechanisms and targets of Shenfu Injection in the intervention in chronic heart failure(CHF)through the NOD-like receptor thermal protein domain associated protein 3(NLRP3)/caspase-1 signaling pathway.A CHF model was induced in rats by subcutaneous injection of isoproterenol.Model rats were randomly divided into a model group,a Shenfu Injection group,and a MCC950(NLRP3 inhibitor)group,and a blank group was also set up as a control.After 15 days of treatment,echocardiography was performed to measure cardiac function p...