期刊论文

Protective effect and mechanism of Zuogui Jiangtang Jieyu Formula on damage to hippocampal synaptic microenvironment in rats with diabetes-related depression based on microglia-neuron crosstalk signal CD300f/TLR4

中文

中国中药杂志

1001-5302

2024

49

17

4597-4606

10.19540/j.cnki.cjcmm.20240611.707

82104793:国家自然科学基金 82104839:国家自然科学基金 2022JJ30451:湖南省自然科学基金面上项目 2024JJ4033:湖南省自然科学基金优秀青年项目 2024JJ9427:湖南省自然科学基金医卫联合项目 2022RC1226:湖南省三尖创新人才工程湖湘青年英才项目

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探讨左归降糖解郁方调控小胶质细胞免疫受体分子样家族成员f(CD300f)/Toll样受体4(TLR4)信号改善糖尿病并发抑郁症(DD)大鼠海马突触微环境损伤的保护作用及机制。首先通过2周高脂饲料喂养+STZ注射+28 d...展开更多 探讨左归降糖解郁方调控小胶质细胞免疫受体分子样家族成员f(CD300f)/Toll样受体4(TLR4)信号改善糖尿病并发抑郁症(DD)大鼠海马突触微环境损伤的保护作用及机制。首先通过2周高脂饲料喂养+STZ注射+28 d慢性温和不可预测性应激加孤养复制DD大鼠模型,实验设正常组、模型组、CD300f阻断剂组(CLM1,2μg·kg-1)、CD300f激动剂组(Fcγ,5μg·kg-1)、阳性药组(二甲双胍0.18 g·kg-1+氟西汀1...

This study aims to reveal the protective effect and mechanism of Zuogui Jiangtang Jieyu Formula on the damage to hippocampal synaptic microenvironment in rats with diabetes-related depression(DD)via regulating microglia immune receptor moleculelike family member f(CD300...MORE This study aims to reveal the protective effect and mechanism of Zuogui Jiangtang Jieyu Formula on the damage to hippocampal synaptic microenvironment in rats with diabetes-related depression(DD)via regulating microglia immune receptor moleculelike family member f(CD300f)...