期刊论文

中文

湖南中医药大学学报

1674-070X

2018

38

3

261-265

10.3969/j.issn.1674-070X.2018.03.008

国家自然科学基金资助项目（81001494）； 湖南省教育厅重点实验室开放基金项目（15k059）； 湖南省自然科学基金项目（2016JJ4069）；

本校为第一机构

目的 探讨补阳还五汤促进EPCs修复损伤血管内皮的作用,从归巢环节阐释其作用机制,为中医药防治心脑血管疾病提供参考.方法 以补阳还五汤灌胃及尾静脉输注EPCs作用于内皮损伤的模型大鼠,从血管内皮形态、EPCs归巢等方面评价内皮损伤修复情况,从整合素αvβ3和αvβ5介导的SDF-1/CXCR-4信号通路了解该方促进EPCs归巢的机制.结果 与单用EPC组(E组)和单用药物组(b组)比较,补阳还五汤联合EPC组(B组)αvβ3表达显著增加(P

Objective To investigate the role of Buyang Huanwu decoction(BYHWD)in promoting endothelial progenitor cell(EPC)-induced recovery of injuried endothelial cells,and explain the mechanism from EPCs homing.Methods The endothelial injuried rats were given gavage with BYHWD and vena caudalis injection of EPC.The repaired situation of injuried endothelium was observed.The effect of BYHWD on EPC homing was analyzed from integrinαvβ3 and integrinαvβ5-mediated SDF-1/CXCR-4 signaling pathway.Results Compared with group EPC(group E)and BYHED group(gro...