期刊论文

中文

中国比较医学杂志

1671-7856

2015

4

44-47

10.3969/j.issn.1671.7856.2015.004.009

全国第五批老中医药专家学术经验继承项目,湖南省教育厅科研青年项目（编号118092） 2011湖南省大学生研究性学习和创新性实验计划项目（编号481） 湖南省中医药科研计划项目（编号201236） 湖南省中药粉体与创新药物省部共建国家重点实验室培育基地资助.

本校为第一机构

目的：观察加味二陈汤对ApoE－／－小鼠血脂的影响。方法44只ApoE－／－小鼠以高脂饲喂养4周构建AS小鼠模型，分别用辛伐他汀、加味二陈汤对小鼠灌胃给药，8周后处死小鼠，酶法检测血清血脂；每周称取并记录小鼠体重；油红O染色观察小鼠主动脉管腔内粥样斑块；HE染色观察小鼠主动脉管腔内粥样斑块沉积及肝细胞形态。结果加味二陈汤可显著降低小鼠血清中TCHOL、LDL－C水平（ P＜0．01）；各组小鼠体重均有所增加，但模型组小鼠体重略高于空白对照组和加味二陈汤组；油红O染色结果显示加味二陈汤可显著减少ApoE－／－小鼠主动脉管腔内粥样斑块的面积；小鼠主动脉HE染色示加味二陈汤组小鼠主动脉内...

Objective To explore the effects of the Chinese medicine, modified Erchen decoction, on the serum lipid spectrum of ApoE-/-mice, and to explore its possible anti-atherosclerotic mechanism.Methods Forty-four male 7-8-week old ApoE-/-mice were used in this experiment.ApoE-/-mouse models of atherosclerosis were generated by high-cholesterol diet for 4 weeks.And then, they were given simvastatin or modified Erchen decoction by gavage.The body weight of mice was recorded every week, The mice were sacrificed after treated with the drugs for 8 weeks c...