Objective To explore different methods for establishing animal models of Ureaplasma urealyticum ( UU) infection and to select the best method of establishment of this disease .Methods SPF female BALB/c mice and Wistar rats were multiple-infected with small dose of UU liquid or single-infected with high-dose UU liquid, pretreated with estradiol benzoate, to establish models of Ureaplasma urealyticum infection.Cervical secretion was taken for UU culture at 14, 28, 42 and 56 days after the first time UU treatment , and the reproductive organs were taken for histopathological examination.Resu...
