Oxymatrine Inhibits Homocysteine-Mediated Autophagy via MIF/mTOR Signaling in Human Umbilical Vein Endothelial Cells

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhang, Yanyan;Zhang, Yuan;Tang, Jiayu;Zhao, Shuang;Li, Chen;...

通讯作者：

Huang, Yongpan;Yi, Minhan

作者机构：

[Zhao, Shuang; Li, Chen; Zhang, Yanyan] Guizhou Med Univ, Key Lab Optimal Utilizat Nat Med Resources, Guiyang, Guizhou, Peoples R China.

[Zhang, Yuan] Cent S Univ, Xiangya Hosp, Dept Neurol, Changsha, Hunan, Peoples R China.

[Zhang, Yuan] Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USA.

[Tang, Jiayu] Brain Hosp Hunan Prov, Dept Neurol, Changsha, Hunan, Peoples R China.

[Huang, Yongpan] Hunan Acad Chinese Med, Inst Chinese Med, Dept Pharmacol, Changsha, Hunan, Peoples R China.

通讯机构：

[Huang, YP; Yi, MH] C

[Huang, YP; Yi, MH] H

Cent S Univ, Informat Secur & Big Data Res Inst, Changsha, Hunan, Peoples R China.

Hunan Acad Chinese Med Changsha, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

Apoptosis;Autophagy;HUVECs;Homocysteine;Oxymatrine

期刊：

Cellular Physiology and Biochemistry

ISSN：

1015-8987

年：

2018

卷：

期：

页码：

1893-1903

DOI：

10.1159/000487912

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31500999]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2015M582352]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2017JJ2343, 2017JJ3404]

机构署名：

本校为通讯机构

院系归属：

中医学院

药学院

摘要：

Background/Aims: Genetic or nutritional deficiencies in homocysteine (Hcy)metabolism lead to the accumulation of Hcy and its metabolites in the blood. This can lead to hyperhomocysteinemia (HHcy), which is an independent risk factor for cardiovascular disease. Studies have shown that HHcy leads to endothelial dysfunction, a hallmark of atherosclerosis, which may explain this link. The precise mechanism remains unclear, but a strong possibility is excessive HHCy-induced autophagy. Autophagy has been better studied in ischemia/reperfusion (I/R) i...

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Oxymatrine Inhibits Homocysteine-Mediated Autophagy via MIF/mTOR Signaling in Human Umbilical Vein Endothelial Cells

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