The EMT-Related Genes GALNT3 and OAS1 are Associated with Immune Cell Infiltration and Poor Prognosis in Lung Adenocarcinoma

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成果类型：

期刊论文

作者：

Luo, Dan;Fang, Mengying;Shao, Le;Wang, Jue;Liang, Yuling;...

通讯作者：

Yu, Lili;Wu, QB;Fan, XM

作者机构：

[Luo, Dan; Wang, Jue; Liang, Yuling; Yu, Lili; Wu, Qibiao] Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Fac Chinese Med, Taipa 999078, Macao, Peoples R China.

[Luo, Dan; Fan, Xianming; Wang, Wenjun; Gui, Xuemei; Yan, Jie; Fang, Mengying; Liang, Yuling; Chen, Mengqin] Southwest Med Univ, Affiliated Hosp, Dept Resp & Crit Care Med, Luzhou 646099, Sichuan, Peoples R China.

[Luo, Dan; Fan, Xianming; Wang, Wenjun; Gui, Xuemei; Yan, Jie; Fang, Mengying; Liang, Yuling; Chen, Mengqin] Southwest Med Univ, Affiliated Hosp, Inflammat & Allerg Dis Res Unit, Luzhou 646099, Sichuan, Peoples R China.

[Shao, Le] Hunan Univ Chinese Med, Hosp 1, Ctr Med Res & Innovat, Changsha 410021, Hunan, Peoples R China.

[Wu, Qibiao] Guangdong Univ Technol, Guangdong Hong Kong Macao Joint Lab Contaminants, Guangzhou 510520, Peoples R China.

通讯机构：

[Yu, LL; Wu, QB ] M

[Fan, XM ] S

Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Fac Chinese Med, Taipa 999078, Macao, Peoples R China.

Southwest Med Univ, Affiliated Hosp, Dept Resp & Crit Care Med, Luzhou 646099, Sichuan, Peoples R China.

Southwest Med Univ, Affiliated Hosp, Inflammat & Allerg Dis Res Unit, Luzhou 646099, Sichuan, Peoples R China.

语种：

英文

关键词：

EMT;GALNT3;OAS1;immune infiltration;lung adenocarcinoma;prognosis

期刊：

Frontiers in Bioscience-Landmark

ISSN：

2768-6701

年：

2023

卷：

期：

页码：

271

DOI：

10.31083/j.fbl2810271

基金类别：

Southwest Medical University School-level Scientific Research Project [2021ZKQN095]; Science and Technology Development Fund, Macau SAR [0098/2021/A2, 130/2017/A3, 0099/2018/A3]; Science and Technology Planning Project of Guangdong Province [2020B1212030008]; Natural Science Foundation of Sichuan Province [2022NSFSC0046]; Sichuan Science and Technology Program [2022YFS0631]

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本校为其他机构

院系归属：

第一中医临床学院

摘要：

BACKGROUND: Lung cancer is the main cause of cancer-related death, with epithelial-mesenchymal transition (EMT) playing an important role in the development of this disease. The EMT-related genes Polypeptide N-Acetylgalactosaminyltransferase 3 (GALNT3) and 2'-5'-Oligoadenylate Synthetase 1 (OAS1) are involved in numerous tumor processes. Although these genes have been extensively studied in cancer, they have yet to be analyzed by multi-omics in lung adenocarcinoma (LUAD). METHODS: EMT-related genes were identified by R and Venn diagram. Cox regression and Kaplan-Meier analysis were performed t...

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The EMT-Related Genes GALNT3 and OAS1 are Associated with Immune Cell Infiltration and Poor Prognosis in Lung Adenocarcinoma

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