NLRP3 inflammasome activation in the thymus of MPTP-induced Parkinsonian mouse model

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成果类型：

期刊论文

作者：

Wen, Lu;Zhang, Qiu-Shuang;Heng, Yang;Chen, Ying;Wang, Shuo;...

通讯作者：

Yuan, Yu-He;Chen, Nai-Hong

作者机构：

[Wang, Shuo; Wen, Lu; Heng, Yang; Chen, Ying; Zhang, Qiu-Shuang; Chen, Nai-Hong; Yuan, Yu-He] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China.

[Wang, Shuo; Wen, Lu; Heng, Yang; Chen, Ying; Zhang, Qiu-Shuang; Chen, Nai-Hong; Yuan, Yu-He] Chinese Acad Med Sci, Neurosci Ctr, Beijing 100050, Peoples R China.

[Wang, Shuo; Wen, Lu; Heng, Yang; Chen, Ying; Zhang, Qiu-Shuang; Chen, Nai-Hong; Yuan, Yu-He; Chen, NH] Peking Union Med Coll, Xiannongtan St, Beijing 100050, Peoples R China.

[Chen, Nai-Hong] Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Hunan, Peoples R China.

[Yuan, Yu-He; Chen, NH] Chinese Acad Med Sci, Inst Mat Med, Dept Pharmacol, Xiannongtan St, Beijing 100050, Peoples R China.

通讯机构：

[Yuan, YH; Chen, NH] P

[Yuan, YH; Chen, NH] C

Peking Union Med Coll, Xiannongtan St, Beijing 100050, Peoples R China.

Chinese Acad Med Sci, Inst Mat Med, Dept Pharmacol, Xiannongtan St, Beijing 100050, Peoples R China.

语种：

英文

关键词：

Inflammasome;MPTP;NLRP3;Parkinson's disease;Thymus;alpha-Synuclein

期刊：

Toxicology Letters

ISSN：

0378-4274

年：

2018

卷：

288

页码：

1-8

DOI：

10.1016/j.toxlet.2018.02.003

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81773925, 81373997, U1402221, 81573640]; Beijing Natural Science FoundationBeijing Natural Science Foundation [7161011]; CAMS Innovation Fund for Medical Sciences (CIFMS) [2016-I2M-1-004]; Key Research and Development Project of Hunan Province [2015SK2029-1]; Scientific Research Foundation of the Higher Education Institutions of Hunan Province [15K091]

机构署名：

本校为其他机构

院系归属：

药学院

摘要：

Ample evidence shows that Parkinson's disease (PD) is more than simply a central nervous system (CNS) disorder: the immune system appears to participate in PD pathogenesis. Extracellular misfolded alpha-synuclein (alpha-syn) may trigger an inflammatory response in the brain. Abnormal immune responses are involved in the development of PD, but little is known about the relationship between the thymus malfunction and the pathogenesis of PD. The present study investigated 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced impairment in thymus and explored possible mechanisms involved in ...

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NLRP3 inflammasome activation in the thymus of MPTP-induced Parkinsonian mouse model

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