PCSK9 inhibitors for anti-inflammation in atherosclerosis: protocol for a systematic review and meta-analysis of randomised controlled trials

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Luo, Jichang;Liao, Wanying;Wang, Xue;Xu, Ran;Li, Wei;...

通讯作者：

Yang, B.;Jiao, L.

作者机构：

[Jiao, Liqun; Xu, Ran; Yang, Bin; Wang, Tao; Luo, Jichang; Ma, Yan] China Int Neurosci Inst China INI, Beijing, Peoples R China.

[Jiao, Liqun; Xu, Ran; Yang, Bin; Wang, Tao; Luo, Jichang; Ma, Yan] Capital Med Univ, Dept Neurosurg, Xuanwu Hosp, Beijing, Peoples R China.

[Liao, Wanying] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Beijing, Peoples R China.

[Wang, Xue] Capital Med Univ, Xuanwu Hosp, Med Lib, Beijing, Peoples R China.

[Li, Wei] Liaocheng Peoples Hosp, Dept Neurosurg, Liaocheng, Shandong, Peoples R China.

通讯机构：

[Yang, B.; Jiao, L.] C

China International Neuroscience Institute (China-INI)China

语种：

英文

关键词：

CLINICAL PHARMACOLOGY;Coronary heart disease;Lipid disorders;Protocols & guidelines;VASCULAR MEDICINE

期刊：

BMJ Open

ISSN：

2044-6055

年：

2022

卷：

期：

页码：

e062046

DOI：

10.1136/bmjopen-2022-062046

基金类别：

This work was supported by the Beijing Science and Technologic Project (Z201100005520019).

机构署名：

本校为其他机构

院系归属：

第一中医临床学院

摘要：

Introduction Atherosclerosis is the leading cause of cardiovascular disease (CVD), which is one of the most common causes of morbidity and mortality worldwide. Lipid accumulation and inflammation play a crucial role in the pathogenesis of atherosclerosis. Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors are an emerging lipid-lowering agent reported as a potential anti-inflammation effect in the prevention of CVD. However, the anti-inflammatory effect is still elusive. Therefore, a systematic review and meta-analysis is needed to...

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PCSK9 inhibitors for anti-inflammation in atherosclerosis: protocol for a systematic review and meta-analysis of randomised controlled trials

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