A20 as a novel target for the anti-neuroinflammatory effect of chrysin via inhibition of NF-kappaB signaling pathway.

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成果类型：

期刊论文

作者：

Li, Zhipeng*;Chu, Shifeng;He, Wenbin;Zhang, Zhao;Liu, Jiaqi;...

通讯作者：

Li, Zhipeng;Li, Defang;Chen, Naihong

作者机构：

[Li, Defang; Li, Zhipeng; Li, ZP; Li, DF] Binzhou Med Univ, Sch Integrated Tradit Chinese & Western Med, Yantai 264003, Shandong, Peoples R China.

[He, Wenbin; Yan, Xu; Liu, Jiaqi; Li, ZP; Chen, NH; Chen, Naihong; Cui, Liyuan; Li, Zhipeng; Zhang, Zhao; Chu, Shifeng] Chinese Acad Med Sci, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med, Beijing 100050, Peoples R China.

[He, Wenbin; Yan, Xu; Liu, Jiaqi; Li, ZP; Chen, NH; Chen, Naihong; Cui, Liyuan; Li, Zhipeng; Zhang, Zhao; Chu, Shifeng] Chinese Acad Med Sci, Neurosci Ctr, Beijing 100050, Peoples R China.

[He, Wenbin; Yan, Xu; Liu, Jiaqi; Li, ZP; Chen, NH; Chen, Naihong; Cui, Liyuan; Li, Zhipeng; Zhang, Zhao; Chu, Shifeng] Peking Union Med Coll, Beijing 100050, Peoples R China.

[Chen, Naihong; Chu, Shifeng] Hunan Univ Chinese Med, Coll Pharm, Changsha 410007, Hunan, Peoples R China.

通讯机构：

[Li, ZP; Li, DF] B

[Li, ZP; Chen, NH] C

[Li, ZP; Chen, NH] P

[Chen, Naihong] H

Binzhou Med Univ, Sch Integrated Tradit Chinese & Western Med, Yantai 264003, Shandong, Peoples R China.

语种：

英文

关键词：

A20;Chrysin;NF-kappaB;Neuroinflammation;TRAF6

期刊：

Brain, Behavior, and Immunity

ISSN：

0889-1591

年：

2019

卷：

页码：

228-235

DOI：

10.1016/j.bbi.2019.02.005

基金类别：

This work was supported in part by grants from the National Natural Science Foundation of China (No. 81274122 ).

机构署名：

本校为通讯机构

院系归属：

药学院

摘要：

Neuroinflammation is now recognized to be a feature of many neurological disorders. More accumulated evidences suggested chrysin which was contained in honey, propolis, vegetables, fruits and plants can exert biological activities including anti-neuroinflammatory effects. However, the precise molecular mechanisms of anti-neuroinflammatory effects remain unclear. In the present study, we explored a novel molecular mechanism involved in the anti-neuroinflammatory effect of chrysin. Firstly, we investigated the anti-neuroinflammatory effects of ch...

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A20 as a novel target for the anti-neuroinflammatory effect of chrysin via inhibition of NF-kappaB signaling pathway.

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