期刊论文

中文

中国中医药信息杂志

1005-5304

2015

22

11

42-45

10.3969/j.issn.1005-5304.2015.11.012

国家自然科学基金面上项目（81373576） 湖南省中医药管理局重点项目（201304） 湖南省教育厅优秀青年项目（14B136） 湖南中医药大学中医内科学重点学科（2014-2015年）

本校为第一机构

目的观察加味丹参饮对ApoE-/-动脉粥样硬化(AS)模型小鼠血清一氧化氮(NO)和内皮素(ET)及内皮细胞超微结构的影响,探讨其抗AS作用机制。方法24只7~8周龄ApoE-/-小鼠饲以高脂饲料12周造模,随机分为模型组、阳性药组和加味丹参饮低、高剂量组,每组6只;同品系C57BL/6J小鼠作为空白组,饲以普通饲料。药物干预8周后,摘眼球取血测NO、ET水平,透射电镜观察主动脉内皮细胞超微结构变化。结果与空白组比较,模型组血清NO含量明显降低、ET含量明显升高(P

Objective To investigate the effects of Jiawei Danshen Decoction on endothelial cell ultrastructure, serum NO and ET in apolipoprotein E-knockout atherosclerosis(AS) mice;To discuss its mechanism of anti-atherosclerosis. Methods Totally 24 7-8 weeks old Apo E-/-mice were fed with a high fat diet for 12 weeks until the a mature atherosclerotic plaque was formed. They were randomly divided into four groups:model group, control group, Jiawei Danshen Decoction of low-dose group and high-dose group, 6 mice in each group. Another 6 normal C57BL/6J mice with the same strain were set as the blank grou...