期刊论文

Effects of Compound Baihe Shugan Anshen Decoction on the expression of neurotrophic factor in hippocampal and amygdala of anxious depression model rats

Wang, Y.-H.

中文

中国新药杂志

1003-3734

2019

28

18

2206-2212

10.3969/j.issn.1003-3734.2019.18.007

国家“重大新药创制”科技重大专项资助项目(2017ZX09309026) 湖南省自然科学基金(2019JJ50428) 湖南省教育厅一般项目(18C0371) 中医学一流学科开放基金(2018ZYX50) 湖南中医药大学中医学国内一流建设学科资助项目.

本校为第一且通讯机构

目的:探讨百合疏肝安神汤对焦虑性抑郁模型大鼠海马神经元-杏仁核神经营养因子表达的影响。方法: 72只SD大鼠随机分为空白组、模型组、文拉法辛组( 6.75 mg·kg~(-1)) 、百合疏肝安神汤高、中、低( 18.72,9.36和4.68 g·kg~(-1))剂量组。采用慢性束缚应激联合皮质酮注射( 30 mg·kg~(-1))的方法建立焦虑性抑郁动物模型,于造模同时灌胃( ig)给药,持续21 d。高架十字迷宫测试和强迫游泳实验分别评价大鼠的焦虑和抑郁样行为,高效液相色谱-电化学法检测海马-杏仁核单胺递质5-羟色胺( 5-hydroxytryptamine,5-HT) 、多巴胺( dopamine,DA) 、去甲肾上腺素( norepinephrine,NE)的含量,苏木精-伊红( HE)染...

Objective: To investigate the effects of Compound Baihe Shugan Anshen Decoction on the expression of neurotrophin factor in hippocampal and amygdala in anxious depression model rats. Methods: 72 SD rats were randomly divided into control, model, venlafaxin (6.75 mg•kg-1), high, mid, low-dose Compound Baihe Shugan Anshen Decoction (18.72, 9.36 and 4.68 g•kg-1) groups. Animal model of anxious depression was established by chronic restraint stress combined with corticosterone injection (30 mg•kg-1). The animal model was administered with drugs ...