期刊论文

Effects of Compound Chaijin Jieyu tablets on HPA axis and inflammatory factors in rats with chronic stress depression

中文

中国新药杂志

1003-3734

2020

29

5

514-519

10.3969/j.issn.1003-3734.2020.05.006

2017ZX09309026:重大新药创制"科技重大专项 2018dk2014:湖南省科技厅重点项目 18C0371:湖南省教育厅一般项目 18C0392:湖南省教育厅一般项目 ZYNK201606:教育部重点实验室开放基金 ZYNK201707:教育部重点实验室开放基金 2018JJ3388:湖南省自然科学基金 2019JJ50428:湖南省自然科学基金 18B238:湖南省教育厅优秀青年项目 2018ZYX50:中医学一流学科开放基金项目

本校为第一机构

目的:研究复方柴金解郁片对慢性应激抑郁模型大鼠下丘脑-垂体-肾上腺轴( HPA轴)及炎症因子的影响。方法:连续慢性应激建立抑郁大鼠模型,用开野和水迷宫实验检测大鼠行为学变化,ELISA法检测大鼠血浆中促肾上腺皮质激素释放激素( corticosteroid-releasing hormone,CRH) 、促肾上腺皮质激素( adrenocorticotropic hormone,ACTH) 、皮质酮( corticosterone,CORT)及血清中白介素8( interleukin-8,IL-8) 、白介素18( interleukin 18,IL-18) 、白介素10( interleukin 10,IL-10)的含量。结果:在抑郁大鼠模型中,复方柴金解郁片高剂量组( 2.7 g·kg ~(-1) )明显降低CRH,ACTH,CORT,IL-8,IL-18含量,显著升高...

Objective: To study the effects of Compound Chaijin Jieyu tablets on hypothalamic-pituitary-adrenal axis (HPA axis) and inflammatory factors in rats with chronic stress depression. Methods: A depressed rat model was established by stimulation with continuous chronic stress. The behavioral changes of therats were detected by open field and Morris water maze test. The rat plasma levels of corticosteroid-releasing hormone (CRH), adrenocorticotropic hormone (ACTH), and corticosterone (CORT), as well as the serum levels of interleukin-8 (IL-8), inte...