The ideal tumor targeting drug delivery system should be highly accumulated in the tumor site and release the drug quickly, while there is no leakage in the blood circulation. The accurate tumor targeting can be realized by taking advantage of the changed redox state in tumor environment and the difference of intracellular and extracellular glutathione levels, combined with the nano drug delivery system. This review introduced the principles of redox-sensitive nano drug delivery systems, redox-sensitive bond and their construction methods, also...