期刊论文

Xia, X.-H.;Mo, M.-X.

中文

中国新药杂志

1003-3734

2022

31

14

1372-1379

10.3969/j.issn.1003-3734.2022.14.006

湖南省科技创新计划资助项目（2021RC4064）； 长沙市自然科学基金资助项目（kq2014090,kq2007066,kq2202266）；

本校为第一且通讯机构

关节腔注射是临床治疗骨关节炎的常用给药方法,但存在药物易流失、药效持续时间短等局限性。为提高临床疗效,新型递药系统受到研究者们的青睐。本文以临床治疗骨关节炎的关节腔注射药物为基础,归纳水凝胶、脂质体、微球、纳米粒、病毒载体以及混合型载体等多种新型给药系统的研究情况,总结在骨关节炎治疗中关节腔注射递药系统的构建重点,可为关节腔注射给药治疗骨关节炎的进一步研究提供参考。

Articular cavity injection is a common administration method for the clinical treatment of osteoarthritis, but there are limitations such as easy loss of drugs and short duration of efficacy. In order to improve the clinical curative effect, new drug delivery systems have attracted the attention of researchers. Based on the clinical treatment of osteoarthritis by injecting drugs into the joint cavity, this paper summed up the research progress of various new drug delivery systems, such as hydrogel, liposomes, microspheres, nanoparticles, viral ...