期刊论文

Li, Y.

中文

中国新药杂志

1003-3734

2022

31

14

1411-1419

10.3969/j.issn.1003-3734.2022.14.012

国家自然科学基金(82174343) 2021年湖南省研究生科研创新项目(CX20210712) 湖南中医药大学中药学一流学科项目(校行科字【2018】3号)。

本校为第一机构

目的:优化二氢杨梅素纳米粒(dihydromyricetin nanoparticles,DMY NPs)的制备工艺,对其进行表征,并考察其溶出特征。方法:乳化-超声法制备DMY NPs,运用Plackett-Burman实验设计(Plackett-Burman design,PBD)筛选主要影响因素,采用Box-Behnken优选DMY NPs的提取工艺。泊洛沙姆浓度、给药量以及聚乳酸-羟基乙酸共聚物[poly(lactic-co-glycolic acid),PLGA]与药物的质量浓度比为自变量,以包封率、载药量、平均粒径、聚合物分散性指数(polymer dispersity index,PDI)为考察指标计算总评归一值(overall desirability, OD值),OD值为因变量,通过对自变量与因变量的回归拟合,利用三维曲面图直观分析DMY ...

Objective: To optimize the preparation process of dihydromyricetin nanoparticles (DMY NPs), characterize it and investigate its dissolution characteristics. Methods: DMY NPs were prepared by emulsification-ultrasonic method, the main influencing factors were screened by Plackett-Burman experimental design, and the extraction process of DMY NPs was optimized by Box-Behnken. Poloxamer concentration, dosage, and the mass concentration ratio of PLGA to drug were independent variables, and the encapsulation efficiency, drug loading, average particle...