Resistin-like molecule beta acts as a mitogenic factor in hypoxic pulmonary hypertension via the Ca2+-dependent PI3K/Akt/mTOR and PKC/MAPK signaling pathways

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成果类型：

期刊论文

作者：

Tian, Heshen;Liu, Lei;Wu, Ying;Wang, Ruiwen;Jiang, Yongliang;...

通讯作者：

Dai, Aiguo

作者机构：

[Tian, Heshen; Zhu, Liming; Liu, Guoyu; Hu, Ruicheng; Dai, Aiguo; Jiang, Yongliang; Ji, Lianzhi; Liu, Lei; Wang, Ruiwen; Wu, Ying; Li, Linwei; Fang, Yanyan; Yang, Chulan] Hunan Normal Univ, Affiliated Hosp 1, Hunan Prov Peoples Hosp, Dept Resp Med, Changsha 410016, Hunan, Peoples R China.

[Dai, Aiguo] Hunan Univ Chinese Med, Med Sch, Dept Resp Dis, Changsha 410208, Hunan, Peoples R China.

[Tian, Heshen] Guangzhou Med Univ, Affiliated Hosp 1, State Key Lab Resp Dis, Guangzhou 510120, Guangdong, Peoples R China.

通讯机构：

[Dai, Aiguo] H

Hunan Normal Univ, Affiliated Hosp 1, Hunan Prov Peoples Hosp, Dept Resp Med, Changsha 410016, Hunan, Peoples R China.

Hunan Normal Univ, Affiliated Hosp 1, Hunan Prov Peoples Hosp, Dept Geriatr, Changsha 410016, Hunan, Peoples R China.

Hunan Univ Chinese Med, Med Sch, Dept Resp Dis, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

Hypoxic pulmonary arterial hypertension;Resistin-like molecule β;Ca2+;SOCE;Pulmonary vascular remodeling;Signaling pathway

期刊：

Respiratory Research

ISSN：

1465-993X

年：

2021

卷：

期：

页码：

1-20

DOI：

10.1186/s12931-020-01598-4

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81270118, 81570052]; Natural Science Foundation of Hunan Province, ChinaNatural Science Foundation of Hunan Province [2017JJ2160]

机构署名：

本校为通讯机构

院系归属：

医学院

摘要：

Pulmonary arterial smooth muscle cell (PASMC) proliferation plays a crucial role in hypoxia-induced pulmonary hypertension (HPH). Previous studies have found that resistin-like molecule β (RELM-β) is upregulated de novo in response to hypoxia in cultured human PASMCs (hPASMCs). RELM-β has been reported to promote hPASMC proliferation and is involved in pulmonary vascular remodeling in patients with PAH. However, the expression pattern, effects, and mechanisms of action of RELM-β in HPH remain unclear. We assessed the expression pattern, mit...

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Resistin-like molecule beta acts as a mitogenic factor in hypoxic pulmonary hypertension via the Ca2+-dependent PI3K/Akt/mTOR and PKC/MAPK signaling pathways

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