期刊论文

Qin, L;Qin, Li;Dai, AG

英文

Cell Communication and Signaling

1478-811X

2023

21

1

1-22

10.1186/s12964-022-01032-w

This work was supported by the National Natural Sciences Foundation of China (No. 81973668, 81774130, 81570052, 81270118, 82200066, 82274159), the Natural Science Foundation of Hunan Province (No. 2021JJ30017, 2022JJ80088), the Key Project of the Educational Department of Hunan Province (No. 20A375, 21A0226), Open Fund of the State Key Laboratory Cultivation Base Co-constructed by the Ministry of Traditional Chinese Medicine Powder and Innovative Drug Research in Hunan Province (No. 21PTKF1004), the Scientific Research Project of Changsha Science and Technology Bureau (No. kq2004060), Key Project of Hunan Provincial Health Commission (No.202213055529), Postgraduate Education Innovation and Professional Ability Improvement Project of Hunan province (CX20220823), and First-Class Discipline of Pharmaceutical Science of Hunan.

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Resistin-like molecules (RELMs) are highly cysteine-rich proteins, including RELMα, RELMβ, Resistin, and RELMγ. However, RELMs exhibit significant differences in structure, distribution, and function. The expression of RELMs is regulated by various signaling molecules, such as IL-4, IL-13, and their receptors. In addition, RELMs can mediate numerous signaling pathways, including HMGB1/RAGE, IL-4/IL-4Rα, PI3K/Akt/mTOR signaling pathways, and so on. RELMs proteins are involved in wide range of physiological and pathological processes, includi...