Hypoglycemic flavonoids from Selaginella tamariscina (P.Beauv.) Spring

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成果类型：

期刊论文

作者：

Long, Hong-Ping;Liu, Jian;Xu, Ping-Sheng;Xu, Kang-Ping;Li, Jing*;...

通讯作者：

Tan, Gui-Shan;Li, Jing

作者机构：

[Liu, Jian; Long, Hong-Ping] Hunan Univ Chinese Med, Hosp 1, Changsha 410007, Peoples R China.

[Tan, Gui-Shan; Xu, Ping-Sheng] Cent South Univ, Xiangya Hosp, Phase I Clin Trial Ctr, Changsha 410008, Peoples R China.

[Tan, Gui-Shan; Xu, Kang-Ping] Cent South Univ, Xiangya Sch Pharmaceut Sci, Changsha 410013, Peoples R China.

[Li, Jing; Long, Hong-Ping] Cent South Univ, Xiangya Hosp, Dept Pharm, Changsha 410008, Hunan, Peoples R China.

[Tan, Gui-Shan; Li, Jing] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha 410008, Hunan, Peoples R China.

通讯机构：

[Tan, Gui-Shan; Li, Jing] C

Cent South Univ, Xiangya Hosp, Phase I Clin Trial Ctr, Changsha 410008, Peoples R China.

Cent South Univ, Xiangya Hosp, Dept Pharm, Changsha 410008, Hunan, Peoples R China.

语种：

英文

关键词：

Selaginella tamariscina;Selaginellaceae;Flavonoids;Hypoglycemic activity;Glucokinase

期刊：

Phytochemistry

ISSN：

0031-9422

年：

2022

卷：

195

页码：

113073

DOI：

10.1016/j.phytochem.2021.113073

基金类别：

Construction Program of Hunan's innovative Province (CN)-High-tech Industry Science and Technology Innovation Leading Project [2020SK2002]; Key Project of Changsha Science and Technology Plan [kq1801072]; Changsha Natural Science Foundation [Kq2014143]

机构署名：

本校为第一机构

院系归属：

第一中医临床学院

摘要：

Six flavonoids, namely, three undescribed biflavonoids, one undescribed 8-aryl flavonoid, and two known compounds, were isolated from Selaginella tamariscina (P.Beauv.) Spring. The structures and absolute configurations of those undescribed compounds were established by NMR spectroscopy data, HRESIMS analyses and electronic circular dichroism (ECD) analyses. In addition, all the isolates were evaluated for their hypoglycemic activity in HepG2 cells. Involvenflavone H, I, and J significantly increased glucose consumption in both normal and insulin-resistant HepG2 cells. Interestingly, these thr...

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Hypoglycemic flavonoids from Selaginella tamariscina (P.Beauv.) Spring

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