期刊论文

An Experimental Study on the Effects of DLXNP on Learningand Memory Ability and Cerebral EAAsin Rat Models of Vascular Dementia

中文

湖南中医药大学学报

1674-070X

2002

22

2

4-7，26

10.3969/j.issn.1674-070X.2002.02.002

湖南省科委资助项目 （ 0 2 -96 2 -0 7）；

本校为第一机构

目的探讨血管性痴呆(VD)病理机制并研究丹龙醒脑片(DLXNP)对血管性痴呆大鼠模型脑组织兴奋性氨基酸(EAAs)含量的干预作用.方法除正常对照组及假手术组外,其余各组大鼠均用双侧颈总动脉反复夹闭再灌注配合腹腔注射硝普钠降压方法建立VD大鼠模型.夹闭2次,每次10 min,中间再通10 min.用跳台法观察各组大鼠学习记忆功能;用高效液相色谱分析荧光法(HPLC)检测脑组织谷氨酸(Glu)、天门冬氨酸(Asp)浓度.结果模型组与正常对照组和假手术组相比,跳台实验的错误次数及受电击时间明显增多, 潜伏期明显缩短,学习记忆能力降低,Glu、Asp含量明显升高,丹龙醒脑片大、中剂量组与模型组相比:①跳台实验的错误次数及...

Objective To explore the pathological mechanism of vascular dementia and to investigate DLXNP's intervenient effects on cerebral EAAs. Methods The experimental SD (Sprague-Dauley) rats were divided randomly into 5 groups: normal group, sham operation group, cerebral ischemia reperfusion group, DLXNP group, and nimodipine group. Except animals in the normal group and sham operation one,each of the rats was repeatedly induced lerebral ischemia and reperfused for two times, combined with intraperitoneal injection of sodium nitroprusside to establish the vascular dementia model. Bilateral carotid ...