Mechanism of Pingyang Jiangya Formula in treating hypertension based on network pharmacology and in vivo study

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成果类型：

期刊论文

作者：

刘德果;李姿蓉;陈其华;王宇红;肖长江

通讯作者：

Xiao Changjiang

作者机构：

Graduate School, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China

[陈其华] Department of Chinese Medicine Surgery, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China

Department of Encephalopathy, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, Guangxi 530023, China

[肖长江] Department of Cardiology, Hunan Academy of Traditional Chinese Medicine Affiliated Hospital, Changsha, Hunan 410012, China

[王宇红] State Key Laboratory of Chinese Medicine Powder and Medicine Innovation in Hunan (Incubation), Hunan University of Chinese Medicine, Changsha, Hunan 410208, China

通讯机构：

[Xiao Changjiang] D

Department of Cardiology, Hunan Academy of Traditional Chinese Medicine Affiliated Hospital, Changsha, Hunan 410012, China

语种：

中文

关键词：

Pingyang Jiangya Formula (平阳降压方, PYJYF)

关键词(英文)：

RASS

期刊：

数字中医药(英文)

ISSN：

2096-479X

年：

2021

卷：

期：

页码：

214-228

DOI：

10.1016/j.dcmed.2021.09.006

基金类别：

We thank for the funding support from the National Natural Science Foundation of China (No. 81874464 ), National Major New Drug Development Project (No. 2019ZX09301-103 ), and Provincial Department of Graduate Research Innovation Project of Hunan (No. CX20190565 ).

机构署名：

本校为第一且通讯机构

院系归属：

第一中医临床学院

药学院

研究生院

摘要：

Objective: This study aimed to analyze the mechanism of action of the Pingyang Jiangya Formula (平阳降压方, PYJYF) in treating hypertension, based on network pharmacology, and to verify the subsequent predictions through animal experiments. Methods: The active components and related target genes of PYJYF were screened using the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), Bioinformatics Analysis Tool for Molecular Mechanism of Traditional Chinese Medicine (BATMAN-TCM), Encyclopedia of Traditional Chi...

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