期刊论文

Wang, Wei;Yu, HH

英文

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

1357-2725

2024

169

106550

10.1016/j.biocel.2024.106550

This work was financially supported by National Natural Science Foundation of China (82204766, 82174078, 82074122, 82304878); Natural Science Foundation of Hunan Province (2023JJ40490, 2023JJ30445, 2022JJ40318, 2021JJ30502); Scientific research project of Hunan Provincial Education Department (21B0394, 21A0239); Changjiang Scholars Program in Ministry Education, People’s Republic of China (T2019133); Xiaohe Sci-Tech Talents Special under Hunan Provincial Sci-Tech Talents Sponsorship CRediT authorship contribution statement Shen Xinyang: Methodology. Lin Haokai: Methodology. Sheng Wenbing: Formal analysis. Wang Wei: Writing – review & editing, Project administration, acquisition, Conceptualization. Zheng Hao: Writing – review & editing, Writing – original draft, Methodology, Formal analysis. Yu Huanghe: Writing – review & editing, Supervision, Project administration, Methodology, acquisition, Conceptualization. Li Yunzhe: Writing – original draft, Methodology, Formal analysis, Data curation. Deng

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Tujia ethnomedicine Xuetong (the stems of Kadsura heteroclita) have been widely used in folk for rheumatoid arthritis (RA), which can alleviate rheumatic pain through liquor soaking in folk. In this study, we aimed to evaluate the pharmacological effects and underlying mechanism of Xuetongsu (a key chemical component of Xuetong) on bone destruction. In our previous study, it was found that Xuetong extract can reduce adjuvant arthritic rats paw swelling and inhibit inflammatory factors in serum. Furthermore, Xuetongsu has been demonstrated to in...