期刊论文

Antibacterial effects of Banxia Xiexin decoction and its separated recipes on Helicobacter pylori

中文

湖南中医杂志

1003-7705

2012

28

6

106-108

10.16808/j.cnki.issn1003-7705.2012.06.067

湖南省科学技术厅资助项目（编号:2011SK3101）； 湖南省中医药科研计划重点资助项目（编号:201102）；

本校为第一机构

目的:探讨半夏泻心汤及其拆方抗Hp的作用.方法:运用琼脂扩散法、液体稀释法定性和定量检测半夏泻心汤及其拆方对Hp的抗菌作用 结果:在琼脂扩散法中,半夏泻心汤组对Hp抗菌作用优于辛温组和甘温组,差异有统计学意义(P＜0.05);半夏泻心汤组略优于苦寒组,差异无统计学意义(P＞0.05).在液体稀释法中,半夏泻心汤对Hp的最低抑菌浓度(MIC)与最低杀菌浓度(MBC)均为15.63mg/mL;辛温组和苦寒组对Hp的最低抑菌浓度(MIC)与最低杀菌浓度(MBC)均分别为62.50 mg/mL、31.25mg/mL.均在实验检测的浓度范围内(1.95 mg/mL ～ 250.00 mg/mL).结论:半夏泻心汤有较明显的抗菌作用,其中起优势作用的药物以苦寒药为主.

Objective ： To investigate the antibacterial effects of Banxia Xiexin decoction and its separated recipes on Helicobacter pylori （Hp）. Methods： Agar diffusion and broth dilution methods were used to qualitatively and quantitatively evaluate the antibacterial effects of Banxia Xiexin decoction and its separated recipes on Hp. Results： The agar diffusion method showed that Banxia Xiexin decoction exhibited significantly tvetter antibacterial effect than pungent and warm - natured recipe and sweet and warm - natured recipe （P 〈 O. 05 ） ; B...