期刊论文

Intervention effect of yin - nourishing, blood circulation - activating, and detoxicating prescription on MCP - 1 and NF - κBp65 levels in rats with acute cerebral ischemia

中文

湖南中医杂志

1003-7705

2012

28

5

144-145,148

10.16808/j.cnki.issn1003-7705.2012.05.084

湖南省自然科学基金资助项目（编号：10JJ6047） 湖南省科技计划项目（编号：2011SK3098）

本校为第一机构

目的:观察滋阴活血解毒方对MCAO局灶性脑缺血大鼠脑组织MCP-1、NF-κBp65的表达,探讨其对急性脑缺血后炎症反应的干预作用.方法:将32只SD大鼠随机分为假手术组、模型组、滋阴活血解毒方组(以下简称中药组)和阿加曲班组,每组8只.假手术组仅分离各血管,不做模型处理,其余3组均造MCAO模型,在术后24h断头取脑,采用免疫组化法分析脑缺血部位脑组织MCP-1、NF-κBp65的表达.结果:模型组MCP-1表达高于假手术组(P＜0.05),中药组、阿加曲班组MCP-1表达高于假手术组,差异无统计学意义(P＞0.05);中药组与阿加曲班组均能降低MCP-1的表达,与模型组比较,差异有统计学意义(P＜0.05).模型组、中药组、阿加曲班组N...

Objective： To observe the effect of yin-nourishing,blood circulation-activating,and detoxicating prescription on MCP-1 and NF-κBp65 levels in the rat brain tissue with local cerebral ischemia caused by middle cerebral artery occlusion（MCAO）,and to investigate its intervention effect on inflammatory reaction after acute cerebral ischemia.Methods： Thirty-two SD rats were randomly and equally divided into sham-operation group,model group,yin-nourishing,blood circulation-activating,and detoxicating prescription（YBDP） group,and argatroban gro...