期刊论文

中文

湖南中医杂志

1003-7705

2013

29

4

111-113

10.16808/j.cnki.issn1003-7705.2013.04.066

湖南省自然科学基金资助项目（编号:10JJ2026）；

本校为第一机构

目的:应用彩色超声心动图观察益心泰对慢性心衰大鼠心肌重构的影响.方法:用冠脉结扎法造模,将造模成功的50只健康Wistar雄性大鼠分为5组:模型组,益心泰高、中、低剂量组,培哚普利组,每组10只,于造模成功后第50天开始给药.益心泰高、中、低剂量组均灌服益心泰丸,剂量分别为l0.5g·kg-1·d-1、5.5g·kg-1·d-1、2.5g·kg-1·d-1；培哚普利组灌服4.5g·kg-1·d-1；模型组灌服同培哚普利组同等容积的生量盐水.均每天1次,共用药8周.另设正常对照组10只,对照组不进行药物干预.用药8周后心脏超声检测室间隔厚度(IVS)、左心室收缩期后壁厚度(LVPWs)、左心室舒张期后壁厚度(LVPWd)、左心室舒张末内径(LVE...

Objective：To observe the effect of Yixintai on the myocardial remodeling in rats with chronic heart failure by color Doppler echocardiography. Methods： A rat model of chronic heart failure was induced by coronary artery ligationin all groups, and 50 successful model rats were equally divided into five groups ： model group, high - dose, middle - dose, and low - dose Yixintai groups, perindopril group, and the rats began to receive their respective medications 50 d later. The high - dose, middle - dose, and low - dose Yixintai groups received ...