期刊论文

Effect of Baishile capsules on nerve factor expression in mice with chronic stress depression

中文

湖南中医杂志

1003-7705

2013

29

1

121-123

10.16808/j.cnki.issn1003-7705.2013.01.072

国家自然科学基金项目（编号：81202693） 湖南省教育厅科学研究项目（编号：12C0276）

本校为第一机构

目的:探讨百事乐胶囊对慢性应激抑郁小鼠脑源性神经营养因子（BDNF）和神经生长因子（NGF）表达的影响。方法:将40只小鼠随机分为正常组、模型组、百事乐组和氟西汀组。除正常组外,均给予21d慢性不可预知的应激造模。造模前分别给予蒸馏水、百事乐和氟西汀治疗。使用免疫组织化学法观察其脑组织BDNF、NGF的阳性表达情况。结果:模型组小鼠脑组织中BDNF、NGF阳性表达低于正常组（P

Objective： To investigate the effect of Baishile capsules on the expression of brain-derived neurotrophic factor（BDNF） and nerve growth factor（NGF） in mice with chronic stress depression.Methods： Forty mice were randomly divided into normal group,model group,Baishile group,and fluoxetine group.All but normal group were subjected to unpredictable chronic stress for 21 d to establish a mouse model of depression.Distilled water,Baishile capsules,and fluoxetine were given to the corresponding groups before the model was induced.The expression...