期刊论文

Effect of Baishile capsules on hippocampal MAP - 2 expression in rats with depression induced by chronic stress

中文

湖南中医杂志

1003-7705

2013

29

11

121-124

10.16808/j.cnki.issn1003-7705.2013.11.072

国家自然科学基金资助项目（编号：81202693） 湖南省教育厅资助项目（编号：11A087,12C0276）

本校为第一机构

目的:探讨百事乐胶囊对慢性应激抑郁大鼠海马神经元形态结构和功能的影响.方法:在48只SD大鼠中随机选择12只(雌雄各半)为正常组,不进行任何刺激,正常饲养.对其余大鼠给予21d慢性不可预见性应激造模,造模完成后将其随机分为模型组、百事乐组和氟西汀组,每组12只,雌雄各半.对各组大鼠予相应药物进行灌胃给药治疗,模型组大鼠灌胃蒸馏水,每天1次,灌胃给药1h后,再随机给予1种刺激,持续21d.分别于造模后及给药结束后测定各组大鼠糖水偏好度,尼氏染色观察大鼠海马神经元尼氏体,免疫组化检测大鼠海马MAP-2的表达.结果:与模型组相比,百事乐组和氯西汀组大鼠的糖水偏好度明显提高(P＜0.01);模型组大鼠海马...

Objective ： To investigate the effect of Baishile capsules on the morphological structure and function of hippocampal neurons in rats with depression induced by chronic stress. Methods：Twelve rats（ normal group, male -to -female ratio = 1：1 ）were randomly se- lected from 48 Sprague - Dawley rats to be normally fed without stimulation. Other rats were treated with chronic unpredictable stress for 21 d to establish a rat model of depression, and the treated rats were randomly divided into model group（ n = 12）, Baishile group（ n = 12） ,an...