期刊论文

中文

湖南中医杂志

1003-7705

2013

29

11

124-126+138

10.16808/j.cnki.issn1003-7705.2013.11.073

湖南省中医药科研计划资助项目（编号:2011113）；

本校为第一机构

目的:探讨左金丸对因“束缚—水浸”应激引起的大鼠应激性胃溃疡胃黏膜损伤的保护作用及机制.方法:将60只健康SD雄性大鼠随机分为空白对照组,模型对照组,阳性对照组,左金丸低、中、高剂量组,每组10只.各组预防性给药,空白对照组和模型对照组大鼠均灌胃生理盐水,阳性对照组灌胃奥美拉唑水悬液,左金丸低、中、高剂量组分别灌胃左金丸低、中、高剂量水煎剂,连续5d.末次给药后禁食不禁水24h,采用“束缚—水浸”应激法制备大鼠应激性胃溃疡模型.造模成功后进行胃体形态学观察,测量胃液PH值,计算胃溃疡指数(UI),采用酶联免疫法检测血清中促肾上腺皮质激素(ACTH)、皮质酮(CORT)的含量.结果:左金丸组大鼠...

Objective: To investigate the protective effect of Zuojin pills in rats with stress- induced gastric ulcer caused by restraint-water immersion and the mechanism by which Zuojin pills protect the rats from gastric mucosal injury. Methods: Sixty healthy male Sprague- Dawley rats were randomly divided into blank control group,model control group,positive control group,and low-,middle-,and high- dose Zuojin pill groups. The rats received respective treatments by prophylactic administration for 5 d: the blank control group and model control group received normal saline by gavage; the positive contr...