期刊论文

Effect of caveolin - 1 gene knockout on recovery of neurological function and area of cerebral infarction in mice with cerebral ischemic injury

中文

湖南中医杂志

1003-7705

2014

30

3

112-114

10.16808/j.cnki.issn1003-7705.2014.03.066

国家自然科学基金资助项目（编号:81273989,81202694）；

本校为第一机构

目的:评价小窝蛋白caveolin1在MCAO术后脑损伤中起的作用。方法:将C57/BALB/C小鼠分为正常假手术组和正常模型组,caveolin1基因敲除小鼠分为基因敲除假手术组和基因敲除模型组,每组20只。对两模型组小鼠行MCAO术造成脑缺血损伤模型。分别于造模术后第1、7天行TTC染色评价梗死面积,称大脑干湿重评价脑水肿程度,并进行神经功能评分。结果:与正常小鼠比较,caveolin1基因缺失小鼠的损伤变化增强,恢复速度明显减缓。结论:caveolin1在MCAO脑损伤中可能起保护作用和促恢复作用。

Objective ： To evaluate the role of caveolin - 1 in cerebral injury induced by middle cerebral artery occlusion （MCAO）. Methods ：C57/BALB/c mice were divided into normal sham- operation group （n = 20） and normal model group （n = 20） ,while cave- olin - 1 gene knockout mice were divided into gene knockout sham - operation group （ n = 20） and gene knockout model group （ n = 20）. The mice in model groups were treated by MCAO to establish a model of cerebral ischemic injmT. At 1 and 7 days alter the model was established,TFC staining wa...