期刊论文

中文

湖南中医杂志

1003-7705

2015

31

10

147-149

10.16808/j.cnki.issn1003-7705.2015.10.082

湖南省高校创新平台开放基金项目（编号:12K090）；

本校为第一机构

目的:研究丹龙醒脑方对脑缺血再灌注大鼠神经功能和脑梗死面积的影响.方法:用线栓法制备大鼠大脑中动脉栓塞缺血再灌注模型.造模成功后将48只SD雄性大鼠随机分为模型组,假手术组,尼莫地平组,丹龙醒脑方大、中、小剂量组,每组各8只.分别灌胃等体积蒸溜水、尼莫地平片与不同剂量的丹龙醒脑方.连续灌胃7d后观察神经功能症状评分与脑梗死面积.结果:神经功能评分、脑梗死面积方面,模型组,尼莫地平组及丹龙醒脑方大、中、小剂量组与假手术组比较,差异均有统计学意义(P＜0.01);尼莫地平组及丹龙醒脑方大中小剂量组与模型组比较,差异均有统计学意义(P＜0.05);丹龙醒脑方各剂量组组间比较,差异均无统计学...

Objective： To investigate the effects of Danlong Xingnao prescription on neurological function and infarct area in rats with cerebral ischemia- reperfusion. Methods： Forty- eight male Sprague- Dawley rats were randomly and equally divided into model group,sham operation group,nimodipine group,and high-,medium-,and low- dose Danlong Xingnao prescription groups. All rats except those in the sham operation group were treated with intraluminal suture occlusion of the middle cerebral artery to produce the animal model of ischemia- reperfusion. Dru...