期刊论文

Comparative study on Wittig- Horner reaction and Grignard reaction in synthesis of resveratrol derivative

中文

湖南中医杂志

1003-7705

2015

31

1

142-144

10.16808/j.cnki.issn1003-7705.2015.01.076

(编号:2012163):湖南省中医药管理局科研项目 (编号:174):2013年度湖南省大学生创新性实验计划项目 (编号:2011):湖南省药学重点学科资助

本校为第一机构

目的:白藜芦醇衍生物3,4,5,4’-四羟基二苯乙烯四甲基化物的比较合成研究。方法:以3,4,5-三甲氧基苯甲酸和茴香醛为起始原料,3,4,5-三甲氧基苯甲酸经过Na BH4还原和SOCl2卤代制备成卤代烃,卤代烃经Wittig-Horner反应制备Wittig试剂和Grignard反应制备Grignard试剂。Wittig试剂和Grignard试剂再分别与茴香醛缩合制备3,4,5,4’-四甲氧基二苯乙烯。终产物的结构经由1H-NMR和MS分析确认。结果:经1H-NMR和MS分析确认,采用Wittig-Horner反应和Grignard反应合成3,4,5,4’-四甲氧基二苯乙烯的总得率分别为75.76%、15.96%,二者差异显著。结论:Wittig-Horner反应相对更有利于目标化合物关键步骤中双键的构...

Objective： To conduct a comparative study on the synthesis of the resveratrol derivative 3,4,5,4＇- tetramethoxystilbene. Methods： The 3,4,5- trimethoxybenzoic acid and anisaldehyde were selected as raw materials and were treated by Na BH4 reduction and SOCl2 halogenation to obtain halogenated hydrocarbons,which were subjected to Wittig- Horner reaction and Grignard reaction to obtain Wittig agent and Grignard agent,respectively. The Wittig agent and Grignard agent were separately mixed with anisaldehyde for condensation to obtain 3,4,5,4＇- ...