期刊论文

中文

湖南中医杂志

1003-7705

2015

31

12

159-161

10.16808/j.cnki.issn1003-7705.2015.12.081

本校为第一机构

目的:探讨心痛泰对心肌梗死大鼠血清ET-1、NO的干预作用.方法:制备心肌梗死大鼠模型,随机分成模型组,假手术组,心痛泰低、中、高剂量组及麝香保心丸组.模型组和假手术组以蒸馏水等量灌胃,其余各组分别给予相应药物及相应剂量灌胃,用药2周后分别检测各组大鼠血清ET-1、NO水平及心肌梗死面积.结果:与模型组相比,各用药组的心肌梗死面积均有减小,差异具有统计学意义(P＜0.01);与心痛泰低剂量组相比,心痛泰中、高剂量组及麝香保心丸组梗死面积有减小,差异具有统计学意义(P＜0.01),而心痛泰中、高剂量组及麝香保心丸组三者之间差异无统计学意义(P＞0.05).与假手术组相比,各治疗组及模型组ET-1表达均显...

Objective： To investigate the effect of Xintongtai on the serum levels of endothelin- 1（ ET- 1） and nitric oxide（ NO） in a rat model of myocardial infarction. Methods： The rat model of myocardial infarction was established,and the rats were divided into model group,sham- operation group,low-,middle-,and high- dose Xintongtai groups,and Shexiang Baoxin Pill group. The rats in the model group and the sham- operation group were given the same volume of distilled water by gavage,and the rats in the other groups were given respective doses of ...