期刊论文

中文

湖南中医杂志

1003-7705

2015

31

11

158-161

10.16808/j.cnki.issn1003-7705.2015.11.090

湖南省自然科学基金（联合基金）资助项目（编号:13JJ6088）；

本校为第一机构

目的:观察补肾活血中药方剂对去势大鼠腰椎间盘组织形态学及TNF-仅含量变化的影响.方法:健康雌性SD大鼠40只,分为空白组、假手术组、模型组、补肾活血汤组,各10只.模型组、补肾活血汤组行双侧卵巢切除术制备去势大鼠模型,假手术组在其双侧卵巢旁边分别取和卵巢同等大小的脂肪组织.造模后适应性喂养1周,补肾活血汤灌服补肾活血方药液,其余组灌服等剂量生理盐水,灌胃12周后处死.观察比较各组腰椎间盘组织形态学及TNF-α含量的变化.结果:与空白组比较,模型组腰椎间盘组织退变程度评分增加,脊索细胞计数减少,TNF-α表达增加,差异均有统计学意义(P＜0.01或P＜0.05);与模型组比较,补肾活血汤组腰椎间盘...

Objective ：To observe the effect of traditional Chinese medicine（TCM）prescription with kidney toni- fying and blood circulation - activating effect on the histomorphology of intervertebral disc and content of tumor nec- rosis factor-α （TNF -α）in ovariectomized rats. Methods ：A total of 40 healthy female Sprague -Dawley rats were divided into blank group, sham- operation group, model group ,and kidney- tonifying and blood circulation activa- ting decoction group, with 10 rats in each group. In the model group and kidney -tonifying and bl...