期刊论文

中文

湖南中医杂志

1003-7705

2015

31

6

156-158

10.16808/j.cnki.issn1003-7705.2015.06.086

湖南省教育厅科学重点研究资助项目（编号:10A090）；

本校为第一机构

目的:探讨宁神温胆汤对精神分裂症大鼠大脑诱导型一氧化氮合成酶（i NOS）及一氧化氮（NO）蛋白表达的影响。方法:将40只SD雌性大鼠随机分为4组:正常组、模型组、宁神温胆汤组、利培酮组,给予正常组、模型组生理盐水灌胃,宁神温胆汤组灌胃中药药液15.2g生药/kg,利培酮组给予药液灌胃0.18mg/kg。1次/d,连续7d。末次给药后对除正常组外的其他3组大鼠腹腔注射阿扑吗啡2mg/kg制备大鼠分裂症模型,对造模后5、10、15min采用刻板评分方法评定各组刻板行为的改变;15min后断头处死,取脑组织,免疫组化法检测i NOS,硝酸还原法检测NO蛋白表达。结果:模型组刻板评分均在0分以上,表明造模成功;与模型组相比,宁...

Objective：To investigate the effects of Ningshen Wendan decoction on inducible nitric oxide syn- thase （iNOS）expression and nitric oxide （NO）production in schizophrenic rats. Methods：Forty female Sprague - Dawley rats were randomly divided into normal group, model group, Ningshen Wendan decoction group, and risperi- done group. The above four groups were given saline solution, saline solution, 15.2g/kg Ningshen Wendan decoc- tion, and 0. 18mg/kg risperidone, respectively, by intragastric administration once daily for seven consecutive day...