期刊论文

中文

湖南中医杂志

1003-7705

2016

32

2

155-157

10.16808/j.cnki.issn1003-7705.2016.02.082

国家自然科学基金资助项目（编号:81273816）；

本校为第一机构

目的:探讨补骨脂素对去势骨质疏松模型大鼠转化生长因子-β（TGF-β）的影响。方法:将雌性SD大鼠72只随机分为假手术组、模型组、戊酸雌二醇阳性对照组、壮骨止痛胶囊组、补骨脂素高剂量组、补骨脂素低剂量组,每组各12只。除假手术组外,其余各组大鼠制备去卵巢骨质疏松症病理模型,术后5d拆线后连续给药13周,每10d称体质量1次,根据体质量调整用药剂量。给药结束后处死大鼠,采用ELISA法检测血清中雌二醇（E2）、TGF-β含量,提取股骨组织mRNA样本进行PCR反应,检测TGF-β基因的表达。结果:与假手术组比较,模型组血清E2水平明显降低（P

Objective： To investigate the effects of psoralen on the transforming growth factor β（ TGF- β） in a rat model of postmenopausal osteoporosis. Methods： Seventy- two female Sprague- Dawley rats were randomly and equally divided into sham surgery group,model group,estradiol valerate（ positive control） group,Zhuanggu Zhitong capsule group,high- dose psoralen group,and low- dose psoralen group. The rat model of osteoporosis was made by ovariectomy in all groups except the sham surgery group. Rats received respective drugs for 13 consecutive ...