期刊论文

中文

湖南中医杂志

1003-7705

2016

32

3

159-161

10.16808/j.cnki.issn1003-7705.2016.03.086

国家自然科学基金资助项目（编号:81273816）；

本校为第一机构

目的:观察补骨脂-淫羊藿药对对去卵巢骨质疏松型大鼠血清中IL-10、TNF-α水平的影响,探讨补骨脂-淫羊藿药对防治绝经后骨质疏松症的作用机制.方法:3月龄SD雌性大鼠40只,分为假手术组、模型组、壮骨止痛胶囊组、阳性对照组、补骨脂-淫羊藿药对组,采用去卵巢3个月制备绝经后骨质疏松大鼠模型,连续灌胃13周后检测比较各组大鼠血清IL-10、TNF-α水平.结果:与模型组比较,补骨脂-淫羊藿药对组能提高骨质疏松模型大鼠血清IL-10水平,但差异无统计学意义(P＞0.05);补骨脂-淫羊藿药对组能显著降低模型大鼠血清TNF-α水平,差异有统计学意义(P＜0.01).结论:补骨脂-淫羊藿药对可以抑制骨吸收,调节成骨细胞与破...

Objective： To observe the effects of Fructus Psoraleae- Herba Epimedii on serum interleukin- 10（ IL- 10） and tumor necrosis factor- alpha（ TNF- α） levels in ovariectomized rats with osteoporosis and to investigate the mechanism of action of Fructus Psoraleae- Herba Epimedii in preventing and treating postmenopausal osteoporosis. Methods： Forty female Sprague- Dawley rats（ 3 months old） were randomly divided into sham- operation group,model group,bone- strengthening and pain- relieving capsule group,positive control group,and Fructus Ps...