期刊论文

中文

湖南中医杂志

1003-7705

2017

33

1

136-138

10.16808/j.cnki.issn1003-7705.2017.01.064

国家自然科学基金资助项目（编号:81273816）；

本校为第一机构

目的:观察"女贞子-枸杞子"对去卵巢骨质疏松症大鼠血清中IL-10、IL-17水平的影响,探讨补阴药防治绝经后骨质疏松症的作用机制。方法:3月龄SD雌性大鼠60只,分为假手术组、模型组、阳性对照组、壮骨止痛胶囊组、女贞子-枸杞子组,对除假手术组外的其余组大鼠去卵巢3个月,制备绝经后骨质疏松症病理模型,手术后1周灌胃给药,连续13周。检测比较各组大鼠血清IL-10、IL-17水平。结果:与模型组比较,壮骨止痛胶囊组、女贞子-枸杞子组血清IL-10水平均明显升高,差异有统计学意义（P0.05）。结论:女贞子-枸杞子能明显升高骨质疏松模型雌鼠血清IL-10水平,且能小幅度提高其IL-17水平,从而达到抗绝经后骨质疏松的...

Objective：To investigate the effect of ＂glossy privet fruit- Lycium barbarum L. ＂ on the serum levels of interleukin -10（ IL- 10）and interleukin -17 （IL- 17 ）in ovariectomized rats with osteoporosis and the mechanism of action of yin - tonifying drugs in the prevention and treatment of postmenopausal osteoporosis. Methods ： A total of 60 female Sprague - Dawley rats aged 3 months were randomly divided into sham - operation group, model group, positive control group, Zhuanggu Zhitong capsule group, and glossy privet fruit - Lycium barbar...