Objective :To investigate the process eonditions for the liquid -state fermentation of Poria cocos strains for the synthesis of Poria cocos triterqene. Methods:A systematic analysis was performed for the process of liquid - state fermentation of Poria cocos strains to synthesize Poria cocos triterpene from the perspectives of carbon source, ni- trogen source,metal ions, eofaetors, and initial pH value. Results:The best carbon source was glucose and the best nitrogen source was corn steep powder. The metal ions added were ZnSO4, MnSO4, CuSO4 ...