期刊论文

中文

湖南中医杂志

1003-7705

2017

33

12

131-133

10.16808/j.cnki.issn1003-7705.2017.12.062

湖南省自然科学基金资助项目（编号:14JJ7087）； 湖南省中医药研究院课题；

本校为第一机构

目的：观察柔肝通络汤对脑缺血大鼠内皮祖细胞（Endothelial Progenitor Cells,EPCs）的影响,探讨其改善脑缺血神经功能缺损的可能机制。方法：采用线栓法制备大脑中动脉闭塞的脑缺血大鼠模型,随机分为0.9%氯化钠注射液组、辛伐他汀组、柔肝通络汤组,每组各10只;另取10只设为假手术组。各组分别于造模成功后第1天开始灌胃给药,连续7d。采用Longa神经功能评分评价造模术后3h及给药前后各组大鼠神经功能缺损情况,于造模前及给药前后使用CD_（34）、CD_（133）双抗体标记结合流式细胞仪检测各组大鼠外周血EPCs数量。结果：各治疗组给药前Longa评分均较造模术后3h降低;给药后Longa评分柔肝通络汤组、...

Objective：To investigate the effect of Rougan Tongluo decoction on endothelial progenitor cells（EPCs） in rats with cerebral ischemia and its possible mechanism in improving neurological defects induced by cerebral ischemia.Methods：The suture method was used to establish a rat model of cerebral ischemia with middle cerebral artery occlusion.The rats were randomly divided into 0.9% sodium chloride injection group,simvastatin group,and Rougan Tongluo decoction group,with 10 rats in each group,and another 10 rats were selected as sham-operation...