期刊论文

Effect of polydatin on Fas-associated death domain protein expression after cerebral ischemia/reperfusion injury

中文

湖南中医杂志

1003-7705

2017

33

2

132-134

10.16808/j.cnki.issn1003-7705.2017.02.065

湖南省中医药管理局资助项目(编号:201458)；

本校为第一机构

目的:研究虎杖苷对脑缺血再灌注损伤后Fas相关死亡区域(FADD)蛋白表达的影响。方法:将54只大鼠按随机数字表法分为假手术组、模型组、虎杖苷组,通过改良线栓法建立大脑中动脉闭塞局灶性脑缺血模型,采用免疫组化法观察虎杖苷对脑缺血再灌注后FADD蛋白表达的影响。结果:脑缺血再灌注6h后海马处的阳性细胞表达增多,24h达较高水平,至72h呈下降趋势。结论:脑缺血再灌注后FADD蛋白表达显著增强,虎杖苷可通过减少FADD蛋白表达起到脑保护作用。

Objective： To investigate the effect of polydatin on Fas- associated death domain（ FADD） protein expression after cerebral ischemia / reperfusion injury. Methods： A total of 54 rats were randomly divided into sham- operation group,model group,and polydatin group using a random number table,and the modified suture method was used to establish a model of middle cerebral artery occlusion and focal cerebral ischemia. Immunohistochemistry was used to analyze the effect of polydatin on FADD protein expression after cerebral ischemia / reperfusion...