期刊论文

中文

湖南中医杂志

1003-7705

2018

34

3

161-163

10.16808/j.cnki.issn1003-7705.2018.03.072

湖南省教育厅科学研究项目（编号:14C0864）；

本校为第一机构

目的：观察金刚健骨片对骨质疏松症模型大鼠体内OPG/RANKL/RANK系统表达的影响。方法：采用卵巢摘除法建立SD大鼠骨质疏松模型,设立假手术组、模型组（单纯去卵巢组）、雌激素组（尼尔雌醇组）和金刚健骨片组。造模成功后4周开始给药,给药12周后RT-PCR检测各组大鼠骨组织中OPG/RANKL/RANK mRNA的表达。结果：与假手术组比较,模型组的OPG表达降低、RANKL表达增加,差异具有统计学意义（P〈0.05）;与模型组比较,金刚健骨片组和雌激素组的OPG表达增高,RANKL表达降低,差异均有统计学意义（P〈0.05）;金刚健骨片组与雌激素组之间比较,差异无统计学意义（P〉0.05）;RANK的mRNA表达在各组之间比较,差异无...

Objective： To investigate the effect of Jingang Jiangu tablets on the OPG/RANKL/RANK system in a rat model of osteoporosis. Methods： Sprague-Dawley rats were ovariectomized to establish a model of osteoporosis and then divided into sham-operation group,model group（ ovariectomization alone）,estrogen group（ nilestriol）,and Jingang Jiangu tablet group. The drugs were administered since four weeks after the model was established,and RT-PCR was used to measure the mRNA expression of OPG/RANKL/RANK in bone tissue after 12 weeks of drug administ...