期刊论文

中文

湖南中医杂志

1003-7705

2018

34

2

140-143

10.16808/j.cnki.issn1003-7705.2018.02.068

国家自然科学基金资助项目（编号：81473737） 湖南省科技厅资助项目（编号：2014SK3033） 湖南省长沙市科技计划项目（编号：K1308037-21）

本校为第一机构

目的:观察双丹明目胶囊与糖尿病相关的视网膜病变（DR）模型大鼠Akt、eNOS mRNA表达的影响。方法:将33只GK大鼠进行DR模型制备后随机分为3组各11只,分别为阳性药物对照组、双丹明目胶囊组（12.5m L/kg）和模型组,另设11只健康Wistar大鼠为空白组。自造模成功后1周开始灌胃给药,持续2个月。使用RT-PCR技术检测各组大鼠Akt、eNOS mRNA的表达。结果:与空白组比较,模型组大鼠Akt、eNOS mRNA的表达较高（P

Objective：To investigate the effect of Shuangdan Mingmu capsules on the mRNA expression of Akt and en- dothelial nitric oxide synthase （eNOS） in a rat model of diabetic retinopathy. Methods：A total of 33 GK rats were used to establish a model of diabetic retinopathy and then they were randomly divided into positive drug control group, Shuangdan Mingmu capsule group （12.5 ml/kg） ,and model group,with 11 rats in each group. Another 11 healthy Wistar rats were included in blank group. The rats were treated with the drug by gavage since one w...