期刊论文

Effect of Chaowei Zhongtong Patch on tumor necrosis factor-α in synovial fluid in rabbits with knee osteoarthritis

中文

湖南中医杂志

1003-7705

2018

34

1

154-156

10.16808/j.cnki.issn1003-7705.2018.01.071

湖南省科技厅资助项目（编号:2011SK3102）； 湖南省教育厅资助项目（编号:17C1218）；

本校为第一机构

目的:观察超微肿痛贴对兔膝骨性关节炎中肿瘤坏死因子-α(TNF-α)表达水平的影响,研究其治疗膝骨性关节炎的机制.方法:将40只实验兔随机分为4组各10只,即超微肿痛贴组、狗皮膏药组、模型组、正常组.采用改良Hulth造模法制备膝骨性关节炎模型,治疗6周后抽取关节液,采用双抗体夹心酶联免疫吸附法(ELISA)测定各组兔膝关节液中TNF-α水平.结果:与正常组比较,超微肿痛贴组及狗皮膏药组中TNF-α的表达均有明显下降(P＜0.01),且治疗组改善情况明显优于对照组(P＜0.05).结论:超微肿痛贴以及狗皮膏药可通过降低膝关节液中TNF-α水平对兔膝骨性关节炎起防治作用.

Objective： To investigate the effect of Chaowei Zhongtong Patch on the level of tumor necrosis factor-α（ TNF-α） in synovial fluid in rabbits with knee osteoarthritis and the mechanism of action of Chaowei Zhongtong Patch in the treatment of knee osteoarthritis. Methods： A total of 40 experimental rabbits were randomly divided into Chaowei Zhongtong Patch group,dogskin plastergroup,model group,and normal group,with 10 rabbits in each group. The modified Hulth method was used to establish a model of knee osteoarthritis,and synovial fluid wa...