期刊论文

中文

湖南中医杂志

1003-7705

2018

34

2

146-149

10.16808/j.cnki.issn1003-7705.2018.02.070

本校为第一机构

目的：研究针刺对膝骨关节炎（KOA）大鼠软骨组织中基质金属蛋白酶-3（MMP-3）、基质金属蛋白酶抑制剂-1（TIMP-1）和转化生长因子-β1 （TGF-β1）表达的影响,探讨针刺治疗KOA的作用机制.方法：选用SD大鼠30只,随机分成空白组、模型组和治疗组,模型组和治疗组采用木瓜蛋白酶右后膝关节注射的方法制备大鼠KOA模型,针刺治疗2周后测定各组大鼠滑膜MMP-3、TIMP-1及TGF-β1的含量.结果：模型组软骨组织中MMP-3和TIMP-1含量较空白组显著增多（P＜0.01）,治疗组MMP-3和TIMP-1含量较模型组显著降低（P＜0.05）,但仍然略高于空白组;模型组软骨组织中TGF-β1含量较空白组显著降低（P＜0.01）,治疗组TGF-β...

Objective： To investigate the effect of acupuncture on the expression of matrix metalloproteinase - 3 （ MMP - 3 ）, tissue inhibitor of metalloproteinase - 1 （ TIMP - 1 ）, and transforming growth factor - beta 1 （ TGF - β1 ） in cartilage tissue in rats with knee osteoarthritis （ KOA）, as well as the mechanism of action of acupuncture in the treatment of KOA. Methods ：A total of 30 Sprague -Dawley were randomly divided into blank group, model group, and treatment group. The rats in the model group and the treatment group were used to e...