期刊论文

中文

湖南中医杂志

1003-7705

2019

35

11

136-138

10.16808/j.cnki.issn1003-7705.2019.11.061

湖南省中医药管理局项目（编号:600110977）；

本校为第一机构

目的:研究青风藤联合黑顺片对大鼠胶原型关节炎（CIA）的疗效。方法:将40只雌性SD大鼠随机分为空白组、模型组、阳性对照组、青风藤联合黑顺片组,每组10只。对除空白组外的其余组大鼠进行生II型胶原诱导的CIA模型制备,初次免疫7d后再次免疫时各组开始灌胃给药,空白组和模型组予0. 9%氯化钠注射液（2ml/只）,阳性对照组予吲哚美辛（1. 0g/kg）,青风藤联合黑顺片组予青风藤+黑顺片（1. 08g/kg+1. 35g/kg）。观察大鼠一般情况,测取足肿胀度,采用ELISA法检测血清细胞因子IL-17、IL-23的含量。结果:与模型组比较,药物组大鼠体质量增长快,足肿胀程度减轻,IL-17、IL-23含量降低,差异均有统计学意义（P ...

Objective: To investigate the effect of Sinomenium acutum combined with Radix Aconiti Lateralis Preparata slices in the treatment of collagen-induced arthritis(CIA) in rats. Methods: A total of 40 female Sprague-Dawley rats were randomly divided into blank group,model group,positive control group,and Sinomenium acutum + Radix Aconiti Lateralis Preparata slices group,with 10 rats in each group. All rats except those in the blank group were used to establish a model of CIA induced by type II collagen,and drugs were given by gavage since re-immunization on day 7 after initial immunization. The ra...