期刊论文

中文

湖南中医杂志

1003-7705

2024

40

02

163-167

10.16808/j.cnki.issn1003-7705.2024.02.036

99-16:湖南省政府特批专项 B2023020:湖南省中医药科研计划项目 22B0359:湖南省教育厅科学研究项目

本校为第一机构

目的:证实麻杏石甘汤对脂多糖(LPS)诱导的发热模型大鼠的解热作用,探究其解热机制及其对大鼠脑组织硫化氢(H2S)/胱硫醚-β-合成酶(CBS)体系的影响.方法:将50只无特定病原体(SPF)SD大鼠随机分为空白组、对照组(蒸馏水)、阿司匹林组(0.125 g/kg阿司匹林肠溶片)、麻杏石甘汤低剂量组(3.125 g/kg麻杏石甘汤)、麻杏石甘汤高剂量组(6.250 g/kg麻杏石甘汤),每组各10只.连续灌胃5 d,末次灌胃1 h后,各给药组予以腹腔注射20 μg/kg LPS溶液诱导大鼠出现发热模型,空白组予以等剂量0.9％氯化钠注射液.记录造模后5 h内大鼠肛温的变化情况.末次体温测量后,腹腔注射3％戊巴比妥钠麻醉大鼠,经腹主动脉收集血液,通...

Objective:To investigate the antipyretic effect of Maxing Shigan decoction in a rat model of pyrexia in-duced by lipopolysaccharide(LPS)and related mechanisms,as well as its effect on the hydrogen sulfide(H2S)/cystathi-onine-β-synthase(CBS)system in rat brain tissue.Methods:A total of 50 specific pathogen-free Sprague-Dawley rats were randomly divided into blank group,control group(distilled water),aspirin group(0.125 g/kg enteric-coated aspirin tablets),low-dose Maxing Shigan decoction group(3.125 g/kg Maxing Shigan decction),and high-dose Ma...