期刊论文

Guiding significance of TCM holistic view in clinical treatment based on the effect of Qingre Jiedu Huazhuo tablets on pancreatic injury in rats with intestinal endotoxemia

中文

湖南中医杂志

1003-7705

2017

33

5

158-160+171

10.16808/j.cnki.issn1003-7705.2017.05.073

湖南省教育厅重点资助项目（编号：12A101） 湖南中医药大学中医临床基础重点学科资助项目

本校为第一机构

目的：基于清热解毒化浊片对肠源性内毒素血症（Intestinal endotoxemia,IETM）大鼠胰损伤作用探讨中医整体观对临床治疗的指导意义。方法：将70只SD大鼠随机分为正常组10只、模型组60只。模型组采用乙醇及高脂饲料喂养建立大鼠IETM胰腺损伤模型,8周末随机取20只模型大鼠确定造模成功,剩余40只大鼠分为模型组和清化组各20只,连续给药4周后,分别从腹主动脉采血检测内毒素,取胰腺组织予免疫组化法观察各组胰腺血小板内皮细胞黏附分子-1（PECAM-1）、白细胞介素-1（IL-1）及白细胞介素-4（IL-4）的表达,HE染色观察胰腺病理形态改变。结果：与模型组比较,清化组血浆内毒素、PECAM-1、IL-1下降（P〈0...

Objective ：To investigate the guiding significance of traditional Chinese medicine （TCM）holistic view in clinical treatment based on the effect of Qingre Jiedu Huazhuo tablets on pancreatic injury in rats with intestinal endotoxemia （IETM）. Methods ： A total of 70 Sprague - Dawley rats were randomly divided into normal group with 10 rats and model group with 60 rats. A rat model of pancreatic injury in IETM was established by alcohol and high - fat feed. At the end of week 8,20 rats were randomly selected to confirm whether the model was ...