期刊论文

Toxicologic study on liuwei yinxing capsule

中文

中国临床保健杂志

1672-6790

2007

10

4

387-389

10.3969/j.issn.1672-6790.2007.04.021

本校为第一机构

目的 观察动物口服六味银杏胶囊的急性毒性和长期毒性反应.方法 采用最大给药量法测定小鼠口服六味银杏胶囊的急性毒性;以20.0,10.0,5.0 g生药·kg-1·d-1 3个剂量的六味银杏胶囊(相当于临床用量68、34、17倍)灌胃 SD大鼠,连续24周,观察服药24周及停药4周后,大鼠的生长发育、血液学、血液生化学、组织病理指标的变化.结果 小鼠1 天内口服六味银杏胶囊最大给药量为190.0 g生药/kg,相当于临床用量的700倍.长期毒性实验中,各剂量组与空白对照组比较,大鼠一般状况,体重增长,血液学、血液生化指标,主要脏器系数,肉眼观察及镜下组织形态学观察均无明显差异或异常.结论 六味银杏胶囊临床用药范围内...

Objective To abserve the acute toxicity in mice and the long-term toxicity of Liuwei Yinxing Capsule （LWYX） in rats. Methods The maximum administration dosage （ MAD ） of LWYX were determined by iq administration in mice. 120 SD rats were randomly divided into four groups ：high, middle, and low dose of LWYX and control group. LWYX was continuously administrated for 24 weeks. When the experiment was finished and withdrawed for 4 weeks, rats were killed and the growth condition, blood cell counting and biochemical targets were measured. Histo...