期刊论文

Effects of Xiangpi Shengji Cream on TGF-β and FN in New Granulation Tissue of Rats with Phase HI Pressure Ulcers

中文

湖南中医药大学学报

1674-070X

2015

35

7

8-11

10.3969/j.issn.1674-070X.2015.07.003

湖南省科技厅计划项目（2012FJ4354）；

本校为第一机构

目的 研究象皮生肌膏对压疮大鼠新生肉芽组织中转化生长因子-β(transforming growth factor-β,TGF-β)及纤维结合蛋白(fibronectin,FN)含量的影响.方法 180只大鼠中随机取30只大鼠作为空白对照组,对其余150只大鼠进行压疮造模,再随机分为模型组、阳性对照组和实验组,每组30只,模型组予生理盐水纱布外敷,阳性对照组予康惠尔溃疡贴外敷,实验组予象皮生肌膏外敷.治疗后的第7、14、21天每组分别随机选取10只大鼠处死并取相同部位创伤组织制切片,用免疫组化检测TGF-β及FN含量,同时观察三组创面愈合率.结果 实验组愈合所需时间最短、愈合率最高,TGF-β含量在第7天最高且达峰值,FN含量在第14天最高且...

Objective To study the effects of Xingpi Shengji cream on TGF-β and FN in new granulation tissue of rats with phase III pressure ulcers. Methods 30 rats from the 180 rats were randomly selected as the blank control group, the other 150 rats were made model of pressure ulcer. The 150 healthy rats were randomly divided into model group, positive control group and experimental group, with 30 rats in each group. The model group was given physiological saline gauze application, the positive control group was treated with comfeel ulcer paste, and th...