期刊论文

中文

中西医结合心脑血管病杂志

1672-1349

2003

1

12

707-708

10.3969/j.issn.1672-1349.2003.12.016

教育部青年骨干教师科研基金资助项目 （No .2 0 0 0 65）；

本校为第一机构

目的:观察活血化瘀类方对心肌细胞凋亡干预作用.方法:采用结扎冠状动脉左前降支的方法复制急性心肌缺血模型,35条犬随机分成对照组、心肌缺血组、丹参饮组、血府逐瘀汤组、失笑散组、活络效灵丹组、桃红四物汤组,每组5条.采用HE染色及DNA末端标记法(TUNEL)分别观察心肌组织病理变化与心肌细胞凋亡的变化.结果:对照组无细胞变性与坏死,仅见极少量凋亡阳性细胞:心肌缺血组与失笑散组有明显心肌组织坏死,心肌细胞凋亡增多;丹参饮组、血府逐瘀汤组、活络效灵丹组、桃红四物汤组心肌细胞坏死及凋亡均显著减轻.结论:血府逐瘀汤、活络效灵丹、桃红四物汤、丹参饮可有效抑制心肌细胞坏死及凋亡,减轻心肌...

Objective: To explore the effect of HuoXueHuaYu decoctions on myocardial pathology and myocardial cellar apoptosis of experimental acute ischemic myocardium. Methods: Thirty-five dog were randomly divided into 7 groups control group, ischemic group, ShiXiaoSan group, XueFuZhuYu group, HuoLuoXiaoLingDan group, TaoHongSiWuTang group and DanShenYin group.The left anterior descending coronary artery was ligated to make a model of acute ischemic myocardium. The changes in myocardial pathology and cellar apoptosis were detected. Results: The number of myocardium cellar apoptosis in XueFuZhuYu group,...